Controversies of radiotherapy in human epidermal growth factor receptor (HER)-2 positive breast cancer patients
نویسندگان
چکیده
منابع مشابه
Breast Carcinoma; Human Epidermal Growth Factor Receptor-2 (HER-2) and Grading Correlation
Introduction: Overexpression of Human Epidermal Growth factor Receptor-2 (HER-2) is one of the most important prognostic and predictive factors of breast cancer, observed in 25% - 30% of breast carcinoma patients leading to poor prognosis and feasible anti HER-2 antibody drugs. The objective of this study was to evaluate the HER-2 frequency in target population and its correlat...
متن کاملCurrent Therapies for Human Epidermal Growth Factor Receptor 2-Positive Metastatic Breast Cancer Patients
The median survival of patients with human epidermal growth factor receptor 2 (HER2)positive metastatic breast cancer (MBC) has more than doubled, since the discovery of HER2-targeted treatments: it rose from less than 2 years in 2001 (prior introduction of trastuzumab) to more than 4 years in 2017. The initial generation of HER2-targeted therapies included trastuzumab with taxanes in the first...
متن کاملHuman Epidermal Growth Factor Receptor Family (HER) in Gastric Cancer
The epidermal growth factor receptor family consists of four members with similar structures: HER1/erbB1, HER2/erbB2, HER3/erbB3 and HER4/erbB4. The genes encoded for Erb are proto-oncogenes, or precursor genes, which under normal conditions are present in all cells of an organism. Proto-oncogenes can be activated in several ways, most often it is through structural changes of the cell genome s...
متن کاملEffect of simultaneous inhibition of epidermal growth factor receptor and cyclooxygenase-2 in HER-2/neu-positive breast cancer.
PURPOSE HER-2/erbB2/neu is overexpressed in 25% to 30% of all invasive breast cancers and is associated with an aggressive course and reduced survival. HER-2/erbB2/neu breast tumors are frequently associated with up-regulation of cyclooxygenase (COX)-2 and activation of the epidermal growth factor receptor (EGFR) pathway, which promote enhanced cell growth and resistance to apoptosis. This stud...
متن کاملImportance of Ki-67 in human epidermal growth factor receptor 2 positive breast cancer.
PURPOSE The aim of this study was to evaluate the importance of Ki-67 in Human Epidermal Growth Factor Receptor 2 (Her-2) positive breast cancer patients. METHODS We reviewed the records of patients diagnosed with Her-2-positive non-metastatic breast cancer between 2005 and 2011. Paraffin-embedded tissue samples were stained with MIB-1 mouse monoclonal antibody to find Ki-67 levels. Patients ...
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ژورنال
عنوان ژورنال: Biomedical Papers
سال: 2021
ISSN: 1213-8118,1804-7521
DOI: 10.5507/bp.2021.007